MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring 16-amino-acid research compound encoded within mitochondrial DNA (the MT-RNR1 gene), supplied for laboratory research only. First described in 2015, it is studied in metabolic, longevity and exercise-physiology research.
MOTS-c acts as a “mitochondrial hormone” in laboratory models, influencing metabolism, insulin sensitivity and exercise adaptation. It acts primarily on skeletal muscle to enhance fatty acid oxidation and glucose metabolism.
Key Functions Under Study
- Metabolic homeostasis: Reported to influence energy balance by inhibiting the folate-purine-AMPK pathway.
- Exercise response: MOTS-c levels increase significantly during exercise (~12-fold), and it is studied in relation to muscular adaptation.
- Stress signalling: Acts as a signalling molecule that moves to the nucleus under metabolic stress to regulate protective genes.
- Research potential: Studied in preclinical models of age-related metabolic conditions.
Biological Mechanism
Unlike most research compounds, MOTS-c is encoded in the mitochondria rather than the nucleus. It is released into circulation and targets skeletal muscle, and it is reported to decline with age.
Storage: Supplied lyophilised. Store at -20°C; once reconstituted with bacteriostatic water, store at 2°C to 8°C.
For laboratory and research purposes only. Not for human consumption, medical use, or veterinary use.
